2
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6324 | (E/Z)-BIX02188 | 334949-59-6 | ERK , MEK , TGF-beta/Smad |
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, JNK2, and ERK2. | |||
T1744 | BIX02188 | Apoptosis , MEK | |
BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD. |